Apparent Mineralocorticoid Excess due to daily consumption of liquorice - containing tea

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APPARENT MINERALOCORTICOID EXCESS IN THREE SIBLINGS

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Syndrome of Apparent Mineralocorticoid Excess

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Apparent mineralocorticoid excess (AME) syndrome.

Apparent mineralocorticoid excess (AME) syndrome is a rare autosomal recessive disorder due to the deficiency of 11b hydroxysteroid dehydrogenase type 2 enzyme (11beta-HSD2). Mutations in this gene affect the enzymatic activity resulting to an excess of cortisol, which causes its inappropriate access to mineralocorticoid receptor leading to inherited hypertension.This is a potentially fatal but...

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Lower limb monoparesis due to liquorice consumption

Since more than six decades ago, liquorice extracts have been used as treatment of gastroduodenal ulcers or Addison’s disease, as adjuvant sweetener in medical mixtures and even as a sweet for children. However, the first case reports on severe side effects of liquorice consumption were observed in the Netherlands back in the 1940s [1]. Hypokalaemic respiratory muscle paralysis due to liquorice...

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apparent mineralocorticoid excess in three siblings

three siblings (1 boy, 2 girls) with hypertension and hypokalemia are presented, two with low plasma aldosterone and suppressed renin activity and the eldest with a high renin and aldosterone level due to secondary changes in her kidneys. urinary tetrahydrocortisol (thf) was increased relative to tetrahydrocortisone (the). cortisol ring a reduction constant was also lower than normal. these fin...

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ژورنال

عنوان ژورنال: Endocrine Abstracts

سال: 2016

ISSN: 1479-6848

DOI: 10.1530/endoabs.44.ep3